Prior to the 1970s Bipolar Disorders were unsuccessfully treated with antidepressants until the Federal Drug Administration (FDA) approved the use of Lithium. Some patients responded better with litium than with antiseizure drugs such as Tegretol (Carbamazepine) and Depakote (Valproate), or to a combination of such drugs. (Altamura et al., 2011;Continue Reading